It is the 1 lie that changed history and although many Torah/Bible scholars might disagree I’m not sure it couldn’t have been stopped for the better. Jacob lied to his father Issac that he was Esau and received the blessing meant for Esau “which changed history forever. That one lie initially led to Jacob being run out of town by his mother out of fear of Esau’s revenge as well as seeing the tables turned on him when his father in law Laban lied to him. Throughout history this one lie has been used by many an Anti-Semitic to turn good people against the Jewish people even though it was done thousands of years ago by one individual. Maybe if Jacob did a bit more persuasion with his father instead of listening to dear old mom things might have turned out a bit different in his life as well as his ancestors. Jacob was only human and who can truly ignore mom’s pleas but for those who want to use this excuse to continue to hate just remember the person who gave the blessing was Jewish (Issac) and the one who received it and his ancestors have had many strings of pain attached with the words of blessing as well.
SIDE NOTE- If Issac blessed Jacob thinking he was Esau did he really bless Jacob and what does a blessing of a human to another human actually achieve?